NATIONAL OPEN UNIVERSITY OF NIGERIA
14/16 AHMADU BELLO WAY, VICTORIA ISLAND, LAGOS
SCHOOL OF SCIENCE AND TECHNOLOGY
MARCH/APRIL 2014 EXAMINATION
COURSE CODE: CHM 421:
COURSE TITLE: HETEROCYCLIC CHEMISTRY
TIME ALLOWED: 2⅟2 Hours
INSTRUCTION: Answer any four Questions
Question 1
a. Give a brief description of the general physical properties of Quinoline. (6 marks)
b. Discuss on the various uses of Quinoline and its derivatives. (5 marks)
c. List 4 methods of synthesis of Quinoline. (4 marks)
d. Describe briefly the Skraup synthesis of Quinoline showing the reaction pathway. (2⅟2 marks)
Question 2
a. Give a concise description of Quinine and its structure. (6 marks)
b. State 5 uses of Chloroquine. (5 marks)
c. Discuss any 2 chemical properties of Isoquinoline. (4 marks)
d. Describe the biological importance of tryptophan. (2⅟2 marks)
Question 3
a. Describe the compound Indole and draw its structure. (5 marks)
b. Describe any 2 chemical properties or reactions of Indole. (4 marks)
Show the reaction pathway for one of the reactions. (3 marks
c. Describe the compound Serotonin, its use and the structure. (5⅟2 marks)
Question 4
a. Describe the physical and Chemical properties of Benzofuran. (8 marks)
b. Describe the major difference between the chemistry of Chromones and Coumarins. (4 marks)
c. Discuss on any of the synthesis of Chromones and show the reaction pathway. (5⅟2 marks)
Question 5
a. Draw the structure of Quinine. (4 marks)
b. Give a brief description on the uses and activities of the drug. (5⅟2 marks)
c. Describe the synthesis of racemic Warfarin. (8 marks)
Question 6
a. List the methods of Indole synthesis. (4 marks)
b. Indole can be reduced under Birch conditions. Discuss (6 marks)
c. Papaverine and Morphine are found in the latex from poppy seed capsules; differentiate these two compounds in terms of structure and function. (7⅟2 marks)
For the 2015 – till date past questions for this course CLICK HERE
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